Chromosomal deletions and progression of premalignant lesions: less is more.
نویسندگان
چکیده
Cancer Epidemiology, Biomarkers & Prevention and Cancer Prevention Research: Two Journals, a Common Goal. Timothy R. Rebbeck, Powel H. Brown, Ernest T. Hawk, Caryn Lerman, Electra D. Paskett, Thomas A. Sellers, and Scott M. Lippman for the CEBP Senior Editors and CaPR Deputy and Senior Editors ......................................................................................................................393
منابع مشابه
Tissue eosinophils as a histopathological marker in oral premalignant and malignant lesions: a histochemical study
Introduction: Although recent studies show the association of eosinophils with different tumors including oral malignancies, the role of eosinophils in premalignant conditions of the oral cavity is not known precisely. Therefore, this study aimed to determine the number of eosinophils in premalignant and malignant conditions of the oral cavity and its role in progression to malignancy. Materia...
متن کاملI-44: Mutagenesis during Embryogenesis
We developed several novel tools to genome wide screen for CNVs and SNPs in single cells. When applied to cleavage stage embryos from young fertile couples we discovered, unexpectedly, an extremely high incidence of chromosomal instability, a hallmark of tumorigenesis (Vanneste et al., Nature Medicine, 2009; Vanneste et al., Hum.Reprod., 2011). Not only mosaicisms for whole chromosome aneuploid...
متن کاملRole of Mitochondria in Ataxia-Telangiectasia: Investigation of Mitochondrial Deletions and Haplogroups
Ataxia-Telangiectasia (AT) is a rare human neurodegenerative autosomal recessive multisystem disease that is characterized by a wide range of features including, progressive cerebellar ataxia with onset during infancy, occulocutaneous telangiectasia, susceptibility to neoplasia, occulomotor disturbances, chromosomal instability and growth and developmental abnormalities. Mitochondrial DNA (mtDN...
متن کاملA Review of Oral Submucousal Fibrosis, Related Factors, Prognosis and New Therapeutic Approaches
Abstract BACKGROUNackground and AIMD & AIM: Oral Submucous Fibrosis (OSF) is an oral premalignant condition with highest premalignant potential among oral precancerous lesions which characterized with inflammation and progressive fibrosis of submucosal oral tissues (cause to significant irreversible rigidity and trismus). During the years, many classification systems have been propo...
متن کاملGenetic progression and clonal relationship of recurrent premalignant head and neck lesions.
We constructed a preliminary genetic progression model for head and neck squamous cell carcinoma (HNSC) based on the frequency of genetic alterations in preneoplastic and neoplastic lesions from single biopsy specimens. To firmly establish the temporal order of established genetic events in HNSC, we sampled serial biopsies from five patients with recurrent premalignant lesions at a single anato...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Cancer prevention research
دوره 1 6 شماره
صفحات -
تاریخ انتشار 2008